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KMID : 0613820060160020266
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Journal of Life Science
2006 Volume.16 No. 2 p.266 ~ p.273
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Effect of Selenium Yeast on MPTP (1-methyl-4-phenyl-propion-oxypiperidine)-Induced Neurotoxicity in Mice
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Kim Seck-Hwan
Lee Joo-Yeon
Kim Yeo-Jeong
Kang Hye-Ok
Lee Hang-Woo
Choi Jong-Won
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Abstract
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This study is investigated the effect of selenium against neurotoxicity induced by MPTP(1-methy-4- phenyl- propion-oxypiperidine) in mice. In order to demonstrate neuroprotective activity of selenium, mice were administrated orally with selenium(25, 50, 100 ㎍/㎏, once/day) for 10 days, and MPTP(10 ㎎/㎏) was injected subcutaneously into the mice for 6 days from the beginning 1hr before selenium treatment. Test of rota road activity was inhibited by treatment with selenium in MPTP-induced neurotoxicity group when compared to MPTP treatment group in normal mice. Monoamine oxidase(MAO)-B activity and cerebral lipid peroxide content were significantly decreased in the treatment of selenium in MPTP-induced neurotoxicity group when compared to MPTP treatment group in normal mice and MAO-A was not affected. Activities of cerebral superoxide dismutase, catalase and glutathione peroxidase were significantly increased in the treatment of selenium in MPTP-induced neurotoxicity group when compared to MPTP treatment group in normal mice. These results suggest that selenium might be estimated the result from the cooperative action of its inhibitory effect on monoamine oxidase-B with that of the enhancement of antioxidant( SOD, catalase, GSH-Px) defence ability.
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KEYWORD
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Selenium, MPTP, neurotoxicity, MAO-B, antioxidant
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